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Quantity and % of sufferers who have been transfusion dependent at baseline who turned transfusion impartial on treatment1
Depending on the system of action and conclusions in animals, VIDAZA might cause fetal hurt when administered to the Expecting girl.
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VIDAZA was administered in a subcutaneous dose of 75 mg/m² day-to-day for 7 times every single 4 weeks. The dose was improved to one hundred mg/m² if no helpful result was witnessed just after two treatment method cycles. The dose was lessened and/or delayed based upon hematologic response or proof of renal toxicity. People within the observation arm had been allowed by protocol to cross around to VIDAZA if they had will increase in bone marrow blasts, decreases in hemoglobin, boosts in red mobile transfusion specifications, or decreases in platelets, or should they expected a platelet transfusion or designed a medical an infection requiring cure with antibiotics. For purposes of evaluating efficacy, the main endpoint was response charge (as outlined in Desk 4).